What therapy is indicated for a patient with a severe asthma attack?

In the context of a severe asthma attack, the best therapy involves the use of short-acting beta-agonists (SABAs) and systemic corticosteroids. SABAs are effective bronchodilators that provide rapid relief by relaxing the muscles around the airways, making them essential for quickly alleviating acute asthma symptoms. They work within minutes and can help restore airflow during an asthma exacerbation.

Systemic corticosteroids play a crucial role in managing the underlying inflammation associated with an asthma attack. They help reduce swelling, mucus production, and inflammation in the airways, further improving airway function. The combination of a SABA for immediate relief and corticosteroids to address the inflammatory aspect is critical for effective management during a severe episode.

While long-acting beta-agonists (LABAs) can be helpful for long-term control of asthma symptoms, they are not suitable for immediate relief in acute situations. Antihistamines primarily target allergic reactions but do not directly aid in relieving bronchoconstriction in asthma. Oxygen therapy, while essential in certain cases to ensure adequate oxygen saturation, does not address the underlying bronchospasm or inflammation present in a severe asthma attack. Therefore, the combination of SABAs and systemic corticosteroids is the most appropriate and effective